Pseudo four-component reaction of salicylaldehydes and cyclic ketones with two molecules of malononitrile: A facile and efficient way to synthesize 4-[2-(dicyanomethylene)cyclic or heterocyclic]-2-amino-4H-chromenes

Pseudo four-component reaction of salicylaldehydes and cyclic ketones with two molecules of malononitrile: A facile and efficient way to synthesize 4-[2-(dicyanomethylene)cyclic or heterocyclic]-2-amino-4H-chromenes Full article

Journal

Comptes Rendus Chimie
ISSN: 1878-1543 , E-ISSN: 1631-0748

Output data

Year: 2016, Volume: 19, Number: 3, Pages: 293-298 Pages count : 6 DOI: 10.1016/j.crci.2015.11.002

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Bobrovsky Sergey I. ¹ , Nasybullin Ruslan F. ¹ , Ilovaisky Alexey I. ¹ , Merkulova Valentina M. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospect 47, 119991 Moscow, Russia

A new type of catalytic cascade pseudo four-component reaction has been found. The simple and facile pseudo four-component reaction of salicylaldehydes and cyclic or heterocyclic ketones with two molecules of malononitrile catalyzed by sodium acetate at ambient temperature results in the formation of 4-substituted 2-amino-4H-chromenes in 70–90% yields. Thus, a new simple and efficient ‘one-pot’ method to synthesize substituted 2-amino-4H-chromenes was found directly from such reasonable starting compounds as salicylaldehydes, cyclic or heterocyclic ketones and malononitrile.

Elinson M.N. , Vereshchagin A.N. , Bobrovsky S.I. , Nasybullin R.F. , Ilovaisky A.I. , Merkulova V.M.
Pseudo four-component reaction of salicylaldehydes and cyclic ketones with two molecules of malononitrile: A facile and efficient way to synthesize 4-[2-(dicyanomethylene)cyclic or heterocyclic]-2-amino-4H-chromenes
Comptes Rendus Chimie. 2016. V.19. N3. P.293-298. DOI: 10.1016/j.crci.2015.11.002 Scopus OpenAlex

Scopus:	2-s2.0-84951204799
OpenAlex:	W2219593034

DB	Citing
OpenAlex	7
Scopus	5