Polyalkoxyflavonoids as inhibitors of cell division

Polyalkoxyflavonoids as inhibitors of cell division Review

Journal

Russian Chemical Reviews
ISSN: 1468-4837 , E-ISSN: 0036-021X

Output data

Year: 2015, Volume: 84, Number: 2, Pages: 134-158 Pages count : 25 DOI: 10.1070/rcr4449

Authors

Semenov V V ¹ , Semenova M N ²

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Moscow, Russian Federation
2	N. K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russian Federation

Being structural analogues of natural microtubule-destabilizing cytostatics, polyalkoxyflavonoids represent a promising class of compounds for anticancer drug design. The review covers synthetic routes to various polyalkoxyflavonoids and the results of biological assays in vitro on human cancer cells and in vivo using sea urchin embryos as a model. Mechanisms of action and structure ± relationship activity for polyalkoxyflavonoids are discussed.

Semenov V.V. , Semenova M.N.
Polyalkoxyflavonoids as inhibitors of cell division
Russian Chemical Reviews. 2015. V.84. N2. P.134-158. DOI: 10.1070/rcr4449 WOS Scopus OpenAlex

≡ Web of science:	WOS:000350741700003
≡ Scopus:	2-s2.0-84924353812
≡ OpenAlex:	W2038269395