Pseudo‐four‐component synthesis and in silico studies of 5‐(5‐hydroxy‐3‐methyl‐1H‐pyrazol‐4‐yl)‐substituted 5H‐chromeno[2,3‐b]pyridines Full article
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Journal of Heterocyclic Chemistry
ISSN: 0022-152X , E-ISSN: 1943-5193 |
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| Output data | Year: 2021, Volume: 58, Number: 3, Pages: 793-804 Pages count : 12 DOI: 10.1002/jhet.4215 | ||
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Abstract:
Multicomponent reactions (MCRs) are important processes, in which more than three different reactants directly get converted into one new structure bearing most of the atoms of these reactants. It is a very powerful tool in drug discovery and combinational chemistry. A new pseudo-four-component synthetic approach to 5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-substituted 5H-chromeno[2,3-b]pyridines with 68%–95% yields is reported. This MCR opens an efficient and convenient way to substituted 5H-chromeno[2,3-b]pyridines, which are promising compounds in medicinal chemistry and for the treatment of lung cancer through inhibition of aldo-keto reductase 1B10. A new consensus approach of molecular docking and molecular dynamics was applied for the investigation of interaction of synthesized 5H-chromeno[2,3-b]pyridines and aldo-keto reductase 1B10.
Cite:
Ryzhkov F.V.
, Elinson M.N.
, Ryzhkova Y.E.
, Vereshchagin A.N.
, Korolev V.A.
, Egorov M.P.
Pseudo‐four‐component synthesis and in silico studies of 5‐(5‐hydroxy‐3‐methyl‐1H‐pyrazol‐4‐yl)‐substituted 5H‐chromeno[2,3‐b]pyridines
Journal of Heterocyclic Chemistry. 2021. V.58. N3. P.793-804. DOI: 10.1002/jhet.4215 WOS Scopus OpenAlex
Pseudo‐four‐component synthesis and in silico studies of 5‐(5‐hydroxy‐3‐methyl‐1H‐pyrazol‐4‐yl)‐substituted 5H‐chromeno[2,3‐b]pyridines
Journal of Heterocyclic Chemistry. 2021. V.58. N3. P.793-804. DOI: 10.1002/jhet.4215 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:000604131500001 |
| Scopus: | 2-s2.0-85099253989 |
| OpenAlex: | W3114612149 |