QSPR approach to the calculation of rate constants of homolysis of nitro compounds in different states of aggregation 3. The solid phase

QSPR approach to the calculation of rate constants of homolysis of nitro compounds in different states of aggregation 3. The solid phase Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 1995, Том: 44, Номер: 9, Страницы: 1594-1597 Страниц : 4 DOI: 10.1007/bf01151276

Авторы

Sukhachev D.V. ¹ , Pivina T.S. ¹ , Zhokhova N.I. ² , Zefirov N.S. ² , Zeman S. ³

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913, Moscow, Russian Federation
2	Department of Chemistry, M. V. Lomonosov Moscow State University, Vorob'evy Gory, 119899, Moscow, Russian Federation
3	University of Pardubice, CZ-532 10, Pardubice, Czech Republic

A convenient preparative synthesis of cilastatin, an inhibitor of renal dipeptidase used in drugs with the antibiotic imipenem, has been elaborated. The key intermediate in this synthesis is 2-amino-7-chloroheptanoic acid prepared by oxidative cleavage of cycloheptanone followed by bromination of 7-chloroheptanoyl chloride with subsequent amination of the 2-bromo-7-chloroheptanoic acid thus formed. All of the stages of the new synthesis are easily performed, as is the isolation of the intermediate products, and they do not require any organometallic reagents.

Sukhachev D.V. , Pivina T.S. , Zhokhova N.I. , Zefirov N.S. , Zeman S.
QSPR approach to the calculation of rate constants of homolysis of nitro compounds in different states of aggregation 3. The solid phase
Russian Chemical Bulletin. 1995. V.44. N9. P.1594-1597. DOI: 10.1007/bf01151276 WOS Scopus OpenAlex

Web of science:	WOS:A1995TK56300007
Scopus:	2-s2.0-3543005217
OpenAlex:	W4256324448

БД	Цитирований
OpenAlex	1
Scopus	2
Web of science	4