Multicomponent one‐pot synthesis of novel imidazole‐2‐thione derivatives containing allomaltol fragment

Multicomponent one‐pot synthesis of novel imidazole‐2‐thione derivatives containing allomaltol fragment Full article

Journal

Journal of Heterocyclic Chemistry
ISSN: 0022-152X , E-ISSN: 1943-5193

Output data

Year: 2021, Volume: 58, Number: 3, Pages: 864-872 Pages count : 9 DOI: 10.1002/jhet.4222

Authors

Komogortsev Andrey N. ¹ , Melekhina Valeriya G. ¹ , Lichitsky Boris V. ¹ , Minyaev Mikhail E. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Moscow, Russia.

A convenient method for the synthesis of novel imidazole-2-thione derivatives containing allomaltol fragment was elaborated. This approach includes one-pot multicomponent reaction of allomaltol, arylglyoxals, primary amines followed by addition of alkyl or aryl isothiocyanates. It was shown that the key intermediates of the studied process are substituted α-aminoketones and the corresponding imidazolidine-2-thione. The advantages of this synthesis are mild reaction conditions, atom economy, and easy workup procedure, which can avoid chromatographic purifications. The structures of an intermediate imidazolidine-2-thione and one of the final imidazole-2-thiones were determined by X-ray diffraction.

Komogortsev A.N. , Melekhina V.G. , Lichitsky B.V. , Minyaev M.E.
Multicomponent one‐pot synthesis of novel imidazole‐2‐thione derivatives containing allomaltol fragment
Journal of Heterocyclic Chemistry. 2021. V.58. N3. P.864-872. DOI: 10.1002/jhet.4222 WOS Scopus OpenAlex

Web of science:	WOS:000608070100001
Scopus:	2-s2.0-85099404470
OpenAlex:	W3117236993

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OpenAlex	3
Web of science	3
Scopus	3