Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole

Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole Full article

Journal

Synthesis
ISSN: 1437-210X , E-ISSN: 0039-7881

Output data

Year: 2024, Volume: 56, Number: 19, Pages: 3063-3073 Pages count : 11 DOI: 10.1055/s-0043-1775383

Authors

Chernyshev Victor M. ¹ , Ananikov Valentine P. ^1,2 , Shepelenko Konstantin E. ¹ , Gnatiuk Irina G. ¹ , Lavrentev Igor V. ¹ , Minyaev Mikhail E. ²

Affiliations

1	Platov South-Russian State Polytechnic University
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

A new approach for the preparation of a variety of 3-arylated 2-furoic acid derivatives has been developed. The approach involves selective Ru-catalyzed C3-H arylation of the furan moiety of readily available 2-furoyl-1-methylimidazole (using imidazole as a removable N-donor directing group), subsequent N-methylation, and nucleophilic substitution of the imidazole moiety with N, O, S, and C nucleophiles.

Chernyshev V.M. , Ananikov V.P. , Shepelenko K.E. , Gnatiuk I.G. , Lavrentev I.V. , Minyaev M.E.
Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole
Synthesis. 2024. V.56. N19. P.3063-3073. DOI: 10.1055/s-0043-1775383 OpenAlex

OpenAlex:

W4400672586

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