Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents

Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2021, Volume: 70, Number: 3, Pages: 573-579 Pages count : 7 DOI: 10.1007/s11172-021-3127-1

Authors

Fedorov S.N. ¹ , Kuzmich A.S. ¹ , Sabutskii Yu.E. ¹ , Guzii A.G. ¹ , Popov R.S. ¹ , Ogurtsov V.A. ² , Rakitin O.A. ^2,3 , Polonik S.G. ¹

Affiliations

1	G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok. Russian Federation.
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
3	Nanotechnology Education and Research Center, South Ural State University, 76 prosp. V. I. Lenina, 454080 Chelyabinsk, Russian Federation

Nucleophilic substitution of a chlorine atom in 4,5 dichloro-1,2-dithiole-3-thione with per-O-acetyl-1-mercaptho derivatives of D-glucose, D-galactose, D-mannose, D-xylose, L-arabinose, and D-maltose gave six new acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione. These thioglycosides were shown to possess cancer preventive activity on the models of JB6 Cl41 P+ mouse epidermal cells and THP-1 human leukemia cells in soft agar, as well as to inhibit the AP-1-dependent transcriptional activity in JB6 Cl41 luc-AP-1 cells, which suggests the possibility of using the new compounds as potential cancer preventive drugs.

Fedorov S.N. , Kuzmich A.S. , Sabutskii Y.E. , Guzii A.G. , Popov R.S. , Ogurtsov V.A. , Rakitin O.A. , Polonik S.G.
Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents
Russian Chemical Bulletin. 2021. V.70. N3. P.573-579. DOI: 10.1007/s11172-021-3127-1 WOS Scopus OpenAlex

Web of science:	WOS:000633737400024
Scopus:	2-s2.0-85103591711
OpenAlex:	W3144764191

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OpenAlex	6
Scopus	6
Web of science	6