Glycopolymers from Synthetic Fragments (Amides of α-d-Galacturonic Acid with Amino Acids) of Proteus O-Antigens

Glycopolymers from Synthetic Fragments (Amides of α-d-Galacturonic Acid with Amino Acids) of Proteus O-Antigens Full article

Journal

Journal of Carbohydrate Chemistry
ISSN: 0732-8303 , E-ISSN: 1532-2327

Output data

Year: 1994, Volume: 13, Number: 3, Pages: 383-396 Pages count : 14 DOI: 10.1080/07328309408009200

Authors

Chernyak Anatoly Ya. ¹ , Kononov Leonid ¹ , Kochetkov Nikolay ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , Leninsky prospect 47, 117913, Moscow, Russia

Galacturonamides of amino acids (alanine, lysine, serine, and threonine), constituents of Proteus O-specific polysaccharides, have been synthesised. O-tert-Butyl and N∊-tert-butyloxycarbonyl protected amino acid tert-butyl esters were condensed with the 2-azidoethyl α-glycoside of d-galacturonic acid, prepared by Fischer glycosidation. Reduction of the azido group followed by N-acryloylation and deprotection gave the target monomers. By copolymerisation with acryl-amide, these were converted into glycopolymers potentially useful for defining epitopes in Proteus O-antigens.

Chernyak A.Y. , Kononov L. , Kochetkov N.
Glycopolymers from Synthetic Fragments (Amides of α-d-Galacturonic Acid with Amino Acids) of Proteus O-Antigens
Journal of Carbohydrate Chemistry. 1994. V.13. N3. P.383-396. DOI: 10.1080/07328309408009200 WOS Scopus OpenAlex

Web of science:	WOS:A1994NF53500003
Scopus:	2-s2.0-0342337080
OpenAlex:	W2020368032

DB	Citing
OpenAlex	14
Scopus	15
Web of science	16