Sodium Hypophosphite as a Halogen Atom Transfer (XAT) Agent under Photocatalytic Conditions

Sodium Hypophosphite as a Halogen Atom Transfer (XAT) Agent under Photocatalytic Conditions Full article

Journal

Journal of Organic Chemistry
ISSN: 1520-6904 , E-ISSN: 0022-3263

Output data

Year: 2024, Volume: 89, Number: 17, Pages: 12812-12821 Pages count : 10 DOI: 10.1021/acs.joc.4c01412

Authors

Malakhova Ekaterina V. ^1,2 , Kostromitin Vladislav S. ^3,2 , Cheboksarov Demian Y. ^3,2 , Levin Vitalij V. ² , Dilman Alexander D. ²

Affiliations

1	Higher Chemical College, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Miusskaya sq. 9, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation
3	Lomonosov Moscow State University, Department of Chemistry, 119991 Moscow, Leninskie Gory 1-3, Russian Federation

The ability of sodium hypophosphite to generate the phosphorus-centered radical, which can activate the carbon–halogen bond via the halogen atom transfer (XAT) is described. The hydroalkylation of nonactivated alkenes with methyl bromoacetate was performed using sodium hypophosphite as reducing agent under photocatalytic conditions. The key phosphorus centered radical is formed from the hypophosphite anion by hydrogen atom abstraction.

Malakhova E.V. , Kostromitin V.S. , Cheboksarov D.Y. , Levin V.V. , Dilman A.D.
Sodium Hypophosphite as a Halogen Atom Transfer (XAT) Agent under Photocatalytic Conditions
Journal of Organic Chemistry. 2024. V.89. N17. P.12812-12821. DOI: 10.1021/acs.joc.4c01412 Scopus OpenAlex

Scopus:	2-s2.0-85201051165
OpenAlex:	W4401457266

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