Palladium catalyzed C(sp3)–H trifluoroethoxylation | Sciact - научная деятельность

Palladium catalyzed C(sp3)–H trifluoroethoxylation Научная публикация

Журнал

Journal of Catalysis
ISSN: 0021-9517 , E-ISSN: 1090-2694

Вых. Данные

Год: 2024, Том: 435, Номер статьи : 115563, Страниц : DOI: 10.1016/j.jcat.2024.115563

Авторы

Lubov Dmitry P. ¹ , Ivanov Konstantin S. ² , Nefedov Andrey A. ^2,3 , Talsi Evgenii P. ¹ , Bryliakov Konstantin P. ⁴

Организации

1	Boreskov Institute of Catalysis, Pr. Lavrentieva 5, Novosibirsk 630090, Russia
2	Novosibirsk State University, Pirogova 1, Novosibirsk 630090, Russia
3	Vorozhtsov Novosibirsk Institute of Organic Chemistry, Pr. Lavrentieva 9, Novosibirsk 630090, Russia
4	Zelinsky Institute of Organic Chemistry RAS, Leninsky Pr. 47, Moscow 119991, Russia

Palladium(II) complexes of the TPA family (TPA − tris(2-pyridylmethyl)amine) have recently emerged as efficient catalysts of highly 3°-regioselective hydroxylation and chemoselective 2°-ketonization of aliphatic C–H groups with peroxycarboxylic acids. Herewith, we present a novel facet of the catalytic reactivity of such complexes that have been shown to mediate highly efficient (at as low as 0.6 mol. % catalyst loadings) and selective trifluoroethoxylation of organic substrates at benzylic C–H groups, affording the corresponding trifluoroethoxy ethers in up to 73 % isolated yield. The developed synthetic protocol allows for diastereoselective trifluoroethoxylation of complex molecules of natural origin (steroids, terpenoids).

Lubov D.P. , Ivanov K.S. , Nefedov A.A. , Talsi E.P. , Bryliakov K.P.
Palladium catalyzed C(sp3)–H trifluoroethoxylation
Journal of Catalysis. 2024. V.435. 115563 . DOI: 10.1016/j.jcat.2024.115563 WOS Scopus OpenAlex

Web of science:	WOS:001247322700001
Scopus:	2-s2.0-85194074356
OpenAlex:	W4397032446

БД	Цитирований
OpenAlex	3
Scopus	2
Web of science	2