Electrochemical synthesis and studies of substituted 2-thiopyridines | Sciact

Electrochemical synthesis and studies of substituted 2-thiopyridines Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 1994, Том: 43, Номер: 12, Страницы: 2095-2099 Страниц : 5 DOI: 10.1007/bf00700178

Авторы

Kaigorodova E.A. ¹ , Konyushkin L.D. ² , Niyazymbetov M.E. ² , Kvak S.N. ² , Zaplishny V.N. ¹ , Litvinov V.P. ²

Организации

1	Kuban' State Agricultural University, Krasnodar, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Moscow, Russian Federation

A series of substituted 2-alkyl(aryl-, hetaryl-)thiopyridines was prepared by cathodic electrolysis of thiols in the presence of 2-chloro-3-cyano-4-methoxymethyl-6-methylpyridine or 4-chloro-6-methyl-3-oxo-1H-furo[3,4-c]pyridine. The reaction of 3-cyano-4-methoxymethyl-6-methyl-2(1H)-thiopyridone with alkyl halides in the presence of KOH is regioselective and leads toS-alkyl derivatives. The advantages of electrosynthesis for the preparation of 2-alkylthiopyridines fused with 2(5H)-furanone and of 3-aminothieno [2,3-b]pyridines is demonstrated.

Kaigorodova E.A. , Konyushkin L.D. , Niyazymbetov M.E. , Kvak S.N. , Zaplishny V.N. , Litvinov V.P.
Electrochemical synthesis and studies of substituted 2-thiopyridines
Russian Chemical Bulletin. 1994. V.43. N12. P.2095-2099. DOI: 10.1007/bf00700178 WOS Scopus OpenAlex

≡ Web of science:	WOS:A1994QX86900028
≡ Scopus:	2-s2.0-4344664471
≡ OpenAlex:	W2076515414