Comparative assessment of heterogeneous and homogeneous Suzuki-Miyaura catalytic reactions using bio-Profiles and bio-Factors

Comparative assessment of heterogeneous and homogeneous Suzuki-Miyaura catalytic reactions using bio-Profiles and bio-Factors Full article

Journal

Journal of Organometallic Chemistry
ISSN: 1872-8561 , E-ISSN: 0022-328X

Output data

Year: 2022, Volume: 965-966, Article number : 122319, Pages count : DOI: 10.1016/j.jorganchem.2022.122319

Authors

Pentsak Evgeniy O. ¹ , Dzhemileva Lilya U. ¹ , D'yakonov Vladimir A. ¹ , Shaydullin Ruslan R. ^2,1 , Galushko Alexey S. ¹ , Egorova Ksenia S. ¹ , Ananikov Valentine P. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, Moscow, 119991 Russia
2	Department of Chemistry, M. V. Lomonosov Moscow State University, Build. 3, 1 Leninskie Gory, 119991 Moscow, Russian Federation

Transition metals are essential for most catalytic systems in fine organic synthesis. The usage of transition metals has traditionally raised concerns about their toxicity and potential environmental pollution problems. In this context, the issue of preference for supported catalysts, which can be easily removed from the reaction mixture, over metal complex catalysts is of significant relevance. In this work, we used bio-Profiles and bio-Factors of chemical reactions to assess the impact of catalyst type on the toxicity of a reaction system in the practically important Suzuki-Miyaura reaction. The supported catalysts had noticeably lower cytotoxicity than soluble metal complex catalysts. However, the combined effect of supported catalysts on the environment can depend on their preparation procedure and may have a noticeable “neglected” biological impact. Both types of catalysts made no significant contribution to the “overall toxicity” of the systems studied, while common and typically ignored byproducts demonstrated significantly higher “overall” biological influence. In the present study, we describe how to use bio-Profiles in order to visualize and analyze the biological properties of different types of catalytic reactions.

Pentsak E.O. , Dzhemileva L.U. , D'yakonov V.A. , Shaydullin R.R. , Galushko A.S. , Egorova K.S. , Ananikov V.P.
Comparative assessment of heterogeneous and homogeneous Suzuki-Miyaura catalytic reactions using bio-Profiles and bio-Factors
Journal of Organometallic Chemistry. 2022. V.965-966. 122319 . DOI: 10.1016/j.jorganchem.2022.122319 WOS Scopus OpenAlex

Web of science:	WOS:000793624900002
Scopus:	2-s2.0-85127216043
OpenAlex:	W4220914385

DB	Citing
OpenAlex	9
Scopus	9
Web of science	8