On water noncatalytic tandem Knoevenagel–Michael reaction of aldehydes, N,N’-dimethylbarbituric acid and cyclohexane-1,3-diones

On water noncatalytic tandem Knoevenagel–Michael reaction of aldehydes, N,N’-dimethylbarbituric acid and cyclohexane-1,3-diones Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2020, Volume: 30, Number: 1, Pages: 15-17 Pages count : 3 DOI: 10.1016/j.mencom.2020.01.005

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Anisina Yuliya E. ¹ , Leonova Natalia A. ^2,1 , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation

Heating aldehydes, N,N’-dimethylbarbituric acid and cyclohexane-1,3-diones in water results in fast formation of Knoevenagel–Michael adducts in 82–98% yields. This multicomponent process opens facile, efficient and environmentally benign way to the new functionalized [(2-hydroxy-6-oxocyclohex-1-en-1-yl)(aryl)methyl]pyrimidine-2,4(1H,3H)-diones bearing both barbituric acid and cyclohexane-1,3-dionemoieties separated by arylmethylene spacer, which are promising compounds for biomedical applications including analeptics, anti-AIDS and anticancer remedies.

Elinson M.N. , Vereshchagin A.N. , Anisina Y.E. , Leonova N.A. , Egorov M.P.
On water noncatalytic tandem Knoevenagel–Michael reaction of aldehydes, N,N’-dimethylbarbituric acid and cyclohexane-1,3-diones
Mendeleev Communications. 2020. V.30. N1. P.15-17. DOI: 10.1016/j.mencom.2020.01.005 WOS Scopus OpenAlex

Web of science:	WOS:000527920000005
Scopus:	2-s2.0-85080026658
OpenAlex:	W3007281430

DB	Citing
OpenAlex	17
Scopus	15
Web of science	15