Synthesis of glycuronamides of amino acids, constituents of microbial polysaccharides and their conversion into neoglycoconjugates of copolymer type

Synthesis of glycuronamides of amino acids, constituents of microbial polysaccharides and their conversion into neoglycoconjugates of copolymer type Full article

Journal

Glycoconjugate Journal
ISSN: 0282-0080 , E-ISSN: 1573-4986

Output data

Year: 1991, Volume: 8, Number: 2, Pages: 82-89 Pages count : 8 DOI: 10.1007/bf00731016

Authors

Chernyak Anatoly Y. ¹ , Sharma Gangavaram V.M. ¹ , Kononov Leonid O. ¹ , Krishna Palakodety Radha ¹ , Rao Alla V.Rama ² , Kochetkov Nikolay K. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Academy of Sciences, Moscow, USSR
2	Indian Institute of Chemical Technology, Hyderabad, India.

Glycopyranosiduronic acids, amidically linked to amino acids (alanine, serine, threonine, and lysine) were prepared.O-tert-Butyl andNε-tert-butyloxycarbonyl protected amino acidtert-butyl esters were used in ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate promoted condensation with 2-azidoethyl glycosides of glucuronic and galacturonic acid. Reduction of the azido-function followed byN-acryloylation and removal of blocking groups with trifluoroacetic acid gave the target monomers. These were converted into neoglycoconjugates of copolymer type, potentially useful for immunochemical studies.

Chernyak A.Y. , Sharma G.V.M. , Kononov L.O. , Krishna P.R. , Rao A.V.R. , Kochetkov N.K.
Synthesis of glycuronamides of amino acids, constituents of microbial polysaccharides and their conversion into neoglycoconjugates of copolymer type
Glycoconjugate Journal. 1991. V.8. N2. P.82-89. DOI: 10.1007/bf00731016 WOS Scopus OpenAlex

Web of science:	WOS:A1991FV51100004
Scopus:	2-s2.0-0026320701
OpenAlex:	W2087381833

DB	Citing
OpenAlex	16
Scopus	18
Web of science	20