2,4-Diamino-5-(nitromethyl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile

2,4-Diamino-5-(nitromethyl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2022, Volume: 2022, Number: 2, Article number : M1365, Pages count : DOI: 10.3390/m1365

Authors

Ryzhkova Yuliya E. ¹ , Ryzhkov Fedor V. ¹ , Maslov Oleg I. ¹ , Elinson Michail N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

Dimethyl sulfoxide (DMSO) is a cheap polar aprotic solvent used in organic synthesis and in pharmacology because of its low cost, high stability, and non-toxicity. Multicomponent reactions (MCRs) are highly convergent processes and have good atom, step, and pot economies. In this communication, the multicomponent transformation of salicylaldehyde, malononitrile dimer, and nitromethane in DMSO at room temperature was investigated to give 2,4-diamino-5-(nitromethyl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile in good yield. The structure of the earlier unknown compound was confirmed by means of elemental analysis, mass-, nuclear magnetic resonance, and infrared spectroscopy.

Ryzhkova Y.E. , Ryzhkov F.V. , Maslov O.I. , Elinson M.N.
2,4-Diamino-5-(nitromethyl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile
Molbank. 2022. V.2022. N2. M1365 . DOI: 10.3390/m1365 WOS Scopus OpenAlex

≡ Web of science:	WOS:000816199300001
≡ Scopus:	2-s2.0-85130726120
≡ OpenAlex:	W4280611413