N,N'-(2-aryl-2-oxoethane-1,1-diyl)diamides as convenient synthons for the preparation of 3-amido-2-arylbenzofurans

N,N'-(2-aryl-2-oxoethane-1,1-diyl)diamides as convenient synthons for the preparation of 3-amido-2-arylbenzofurans Full article

Journal

Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416

Output data

Year: 2023, Volume: 132, Article number : 133244, Pages count : DOI: 10.1016/j.tet.2022.133244

Authors

Lichitsky Boris V. ¹ , Karibov Turan T. ¹ , Komogortsev Andrey N. ¹ , Melekhina Valeriya G. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr., 47, Moscow 119991, Russian Federation

The general method for the synthesis of 2-arylbenzofuran containing amides was elaborated. The considered approach is based on interaction of various phenols with N,N'-(2-aryl-2-oxoethane-1,1-diyl)diamides, which can be obtained from arylglyoxals and primary amides. The employment of formic acid as a solvent is necessary condition for the presented protocol. The undoubted advantage of the developed method is the possibility of using a wide range of aromatic hydroxyl derivatives. The dignity of this synthesis is readily accessible starting materials, mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purification. The structure of one of the target benzofurans was established by X-ray diffraction.

Lichitsky B.V. , Karibov T.T. , Komogortsev A.N. , Melekhina V.G.
N,N'-(2-aryl-2-oxoethane-1,1-diyl)diamides as convenient synthons for the preparation of 3-amido-2-arylbenzofurans
Tetrahedron. 2023. V.132. 133244 . DOI: 10.1016/j.tet.2022.133244 WOS Scopus OpenAlex

Web of science:	WOS:000964912900001
Scopus:	2-s2.0-85145989287
OpenAlex:	W4313478566

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