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Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors Научная публикация

Журнал Journal of Fluorine Chemistry
ISSN: 1873-3328 , E-ISSN: 0022-1139
Вых. Данные Год: 2023, Том: 266, Номер статьи : 110087, Страниц : DOI: 10.1016/j.jfluchem.2023.110087
Авторы Burmistrov Vladimir V. 1,2 , Morisseau Christophe 2 , Shkineva Tatyana K. 3 , Danilov Dmitry V. 1 , Gladkikh Boris 1 , Butov Gennady M. 1 , Fayzullin Robert R. 4 , Dutova Tatyana Ya. 3 , Hammock Bruce D. 2 , Dalinger Igor L. 3
Организации
1 Department of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky 404121, Russia
2 Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA
3 N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Avenue, Moscow 119991, Russia
4 Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 8 Arbuzov Street, Kazan 420088, Russia

Реферат: A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM. 1-Adamantyl-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (3f, IC50 = 0.8 nM) and 1-[(Adamantan-1-yl)methyl]-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (4f, IC50 = 1.2 nM) were found to be the most potent sEH inhibitors within the described series.
Библиографическая ссылка: Burmistrov V.V. , Morisseau C. , Shkineva T.K. , Danilov D.V. , Gladkikh B. , Butov G.M. , Fayzullin R.R. , Dutova T.Y. , Hammock B.D. , Dalinger I.L.
Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors
Journal of Fluorine Chemistry. 2023. V.266. 110087 . DOI: 10.1016/j.jfluchem.2023.110087 WOS Scopus OpenAlex
Идентификаторы БД:
≡ Web of science: WOS:000923687500001
≡ Scopus: 2-s2.0-85150775612
≡ OpenAlex: W4318937373
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