Tandem diazotization/cyclization approach for the synthesis of a fused 1,2,3-triazinone-furazan/furoxan heterocyclic system

Tandem diazotization/cyclization approach for the synthesis of a fused 1,2,3-triazinone-furazan/furoxan heterocyclic system Full article

Journal

Beilstein Journal of Organic Chemistry
ISSN: 2195-951X , E-ISSN: 1860-5397

Output data

Year: 2024, Volume: 20, Pages: 2342-2348 Pages count : 7 DOI: 10.3762/bjoc.20.200

Authors

Sidunets Yuri A ¹ , Melekhina Valeriya G ¹ , Fershtat Leonid L ^1,2

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Leninsky Prospect, 47, Moscow, Russian Federation.
2	National Research University Higher School of Economics 101000, Myasnitskaya str., 20, Moscow, Russian Federation.

A straightforward protocol for the synthesis of a previously unknown [1,2,5]oxadiazolo[3,4-d][1,2,3]triazin-7(6H)-one heterocyclic system was developed. The described approach is based on tandem diazotization/azo coupling reactions of (1,2,5-oxadiazolyl)carboxamide derivatives bearing both aromatic and aliphatic substituents. The NO-donor ability of the synthesized furoxano[3,4-d][1,2,3]triazin-7(6H)-ones was additionally evaluated. The elaborated method provides access to novel nitrogen heterocyclic compounds with potential applications as drug candidates or thermostable components of functional organic materials.

Sidunets Y.A. , Melekhina V.G. , Fershtat L.L.
Tandem diazotization/cyclization approach for the synthesis of a fused 1,2,3-triazinone-furazan/furoxan heterocyclic system
Beilstein Journal of Organic Chemistry. 2024. V.20. P.2342-2348. DOI: 10.3762/bjoc.20.200 WOS Scopus OpenAlex

Web of science:	WOS:001316601000001
Scopus:	2-s2.0-85204311510
OpenAlex:	W4402807216

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