Photocatalytic method for the generation of the 1,1,1,3,3,3-hexafluoroisopropyl radical

Photocatalytic method for the generation of the 1,1,1,3,3,3-hexafluoroisopropyl radical Full article

Journal

Organic chemistry frontiers
ISSN: 2052-4110 , E-ISSN: 2052-4129

Output data

Year: 2024, Volume: 11, Pages: 4762-4768 Pages count : 7 DOI: 10.1039/d4qo01023j

Authors

Lunkov Sergey S. ¹ , Kostromitin Vladislav S. ^2,1 , Zemtsov Artem A. ¹ , Levin Vitalij V. ¹ , Dilman Alexander D. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation
2	Lomonosov Moscow State University, Department of Chemistry, 119991 Moscow, Leninskie Gory 1-3, Russian Federation

A reagent for the introduction of the 1,1,1,3,3,3-hexafluoroisopropyl group is described. The reagent was obtained on a multi-gram scale in one step from readily available hexafluoroisopropyl alcohol and pentafluoropyridine. Under photoredox conditions, the reagent undergoes facile cleavage of the C–O bond to generate the fluorinated alkyl radical, which can effectively add at C,C double bonds in a variety of atom and group transfer processes.

Lunkov S.S. , Kostromitin V.S. , Zemtsov A.A. , Levin V.V. , Dilman A.D.
Photocatalytic method for the generation of the 1,1,1,3,3,3-hexafluoroisopropyl radical
Organic chemistry frontiers. 2024. V.11. P.4762-4768. DOI: 10.1039/d4qo01023j WOS OpenAlex

Web of science:	WOS:001269899400001
OpenAlex:	W4400288522

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