Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate

Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2024, Volume: 2024, Number: 4, Article number : M1889, Pages count : DOI: 10.3390/m1889

Authors

Potapov Vladimir A. ¹ , Novokshonova Irina A. ¹ , Musalov Maxim V. ¹ , Amosova Svetlana V. ¹ , Rakitin Oleg A. ²

Affiliations

1	A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of The Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, Moscow 119991, Russia

A convenient synthesis of a novel fluoroquinolone precursor, methyl 6,7-difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate, at a 78% yield starting from 3,4-difluorophenyl isothiocyanate was developed. The structure of the product was established by 1H, 13C, and 19F NMR spectroscopy, mass spectrometry, IR spectroscopy and confirmed by elemental analysis. The title compound, containing the pharmacophoric 4-fluorobenzyl group, will be used in the synthesis of novel fluoroquinolone derivatives.

Potapov V.A. , Novokshonova I.A. , Musalov M.V. , Amosova S.V. , Rakitin O.A.
Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate
Molbank. 2024. V.2024. N4. M1889 . DOI: 10.3390/m1889 WOS Scopus OpenAlex

Web of science:	WOS:001384823900001
Scopus:	2-s2.0-85213573753
OpenAlex:	W4402860358

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