Synthesis of the capsular polysaccharide of streptococcus pheumoniae type 14

Synthesis of the capsular polysaccharide of streptococcus pheumoniae type 14 Full article

Journal

Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416

Output data

Year: 1987, Volume: 43, Number: 13, Pages: 3109-3121 Pages count : 13 DOI: 10.1016/s0040-4020(01)86852-6

Authors

Kochetkov N.K. ¹ , Nifant'ev N.E. ¹ , Backinowsky L.V. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the U.S.S.R., MoscowU.S.S.R.

A regular, branched polysaccharide is synthesized whose structure xxx6(Galβ 1–4)GlcNAcβ 1–3Gal β 1–4Glcβ 1xxxn corresponds to that of the capsular poly, sacoharide of streptococcus pheumoniae type 14. Synthesis is accomplished by using a stereo- and regiospecific polycondensation of a tritylated 1,2-0-cyanoethylidene derivative of a tetrasaccha ride repeating unit. The latter is assembled from lactosamine and lactose precursors protected in such a way as to enable selective 0–6-tritylation of the glucosamine moiety.

Kochetkov N.K. , Nifant'ev N.E. , Backinowsky L.V.
Synthesis of the capsular polysaccharide of streptococcus pheumoniae type 14
Tetrahedron. 1987. V.43. N13. P.3109-3121. DOI: 10.1016/s0040-4020(01)86852-6 WOS Scopus OpenAlex

≡ Web of science:	WOS:A1987J275200028
≡ Scopus:	2-s2.0-0000361816
≡ OpenAlex:	W1230219661