Interaction of Difluorocarbene with the Thiocyanate Anion: Access to a Silicon Reagent Bearing the Isothiocyanate Group

Interaction of Difluorocarbene with the Thiocyanate Anion: Access to a Silicon Reagent Bearing the Isothiocyanate Group Full article

Journal

Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052

Output data

Year: 2024, Volume: 26, Pages: 10589-10593 Pages count : 5 DOI: 10.1021/acs.orglett.4c04038

Authors

Trifonov Alexey L. ¹ , Dilman Alexander D. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation

The reaction between (bromodifluoromethyl)trimethylsilane (TMSCF2Br) and potassium thiocyanate providing TMSCF2NCS is described. The process involves the interaction of difluorocarbene with the nitrogen atom of the thiocyanate anion. The obtained silicon reagent served as a source of the fluorinated group and difluorocarbene in the reaction with N-alkyl imines, affording 2-(difluoromethylthio)-4-fluoroimidazoles.

Trifonov A.L. , Dilman A.D.
Interaction of Difluorocarbene with the Thiocyanate Anion: Access to a Silicon Reagent Bearing the Isothiocyanate Group
Organic Letters. 2024. V.26. P.10589-10593. DOI: 10.1021/acs.orglett.4c04038 WOS OpenAlex

Web of science:	WOS:001363834500001
OpenAlex:	W4404721319

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