Synthesis of Pseudooligosaccharides Related to the Capsular Phosphoglycan of Haemophilus influenzae Type a

Synthesis of Pseudooligosaccharides Related to the Capsular Phosphoglycan of Haemophilus influenzae Type a Full article

Journal

Molecules
ISSN: 1420-3049

Output data

Year: 2023, Volume: 28, Number: 15, Article number : 5688, Pages count : DOI: 10.3390/molecules28155688

Authors

Kamneva Anastasia A. ¹ , Yashunsky Dmitry V. ¹ , Khatuntseva Elena A. ¹ , Nifantiev Nikolay E. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Leninsky pr. 47, Moscow 119991, Russia

Synthesis of spacer-armed pseudodi-, pseudotetra-, and pseudohexasaccharides related to the capsular phosphoglycan of Haemophilus influenzae type a, the second most virulent serotype of H. influenzae (after type b), was performed for the first time via iterative chain elongation using H-phosphonate chemistry for the formation of inter-unit phosphodiester bridges. These compounds were prepared for the design of neoglycoconjugates, as exemplified by the transformation of the obtained pseudohexasaccharide derivative into a biotinylated glycoconjugate suitable for use in immunological studies, particularly in diagnostic screening systems as a coating antigen for streptavidin-coated plates and chip slides.

Kamneva A.A. , Yashunsky D.V. , Khatuntseva E.A. , Nifantiev N.E.
Synthesis of Pseudooligosaccharides Related to the Capsular Phosphoglycan of Haemophilus influenzae Type a
Molecules. 2023. V.28. N15. 5688 . DOI: 10.3390/molecules28155688 WOS Scopus OpenAlex

≡ Web of science:	WOS:001045653100001
≡ Scopus:	2-s2.0-85167819026
≡ OpenAlex:	W4385346919