Optimal Balance in the Catalyst Dynamics Enables C(2)−H Arylation of (Benz)imidazoles and (Benz)oxazoles by an In Situ‐Generated Ni/NHC System Full article
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Chemcatchem
ISSN: 1867-3899 , E-ISSN: 1867-3880 |
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| Output data | Year: 2022, Volume: 14, Number: 24, Article number : e202201055, Pages count : DOI: 10.1002/cctc.202201055 | ||||
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Abstract:
An efficient method for the C(2)−H arylation of (benz)imidazoles and (benz)oxazoles with aryl chlorides and aryl bromides under Ni/NHC catalysis has been developed. The main benefit of the method is the in situ generation of active Ni/NHC complexes from the air-tolerant bench-stable precursors NiCl2Py2, IMes⋅HCl, and potassium tert-butoxide, which plays a dual role as base and Ni(II) to Ni(0) reductant. The approach represents a user-friendly alternative for procedures relying on the use of toxic phosphine ligands or unstable air-sensitive Ni(cod)2. The concept highlighted in the present study shows that mapping a competitive picture of catalyst dynamics and revealing the competitive processes towards the destruction and stabilization of catalytically active species enables a highly efficient catalytic system to be built under simple conditions.
Cite:
Khazipov O.V.
, Shepelenko K.E.
, Soliev S.B.
, Nikolaeva K.A.
, Chernyshev V.M.
, Ananikov V.P.
Optimal Balance in the Catalyst Dynamics Enables C(2)−H Arylation of (Benz)imidazoles and (Benz)oxazoles by an In Situ‐Generated Ni/NHC System
Chemcatchem. 2022. V.14. N24. e202201055 . DOI: 10.1002/cctc.202201055 WOS Scopus OpenAlex
Optimal Balance in the Catalyst Dynamics Enables C(2)−H Arylation of (Benz)imidazoles and (Benz)oxazoles by an In Situ‐Generated Ni/NHC System
Chemcatchem. 2022. V.14. N24. e202201055 . DOI: 10.1002/cctc.202201055 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:000887995000001 |
| Scopus: | 2-s2.0-85142396259 |
| OpenAlex: | W4306412176 |