Nucleophilic Functionalization of 2-R-3-Nitropyridines as a Versatile Approach to Novel Fluorescent Molecules

Nucleophilic Functionalization of 2-R-3-Nitropyridines as a Versatile Approach to Novel Fluorescent Molecules Full article

Journal

Molecules
ISSN: 1420-3049

Output data

Year: 2022, Volume: 27, Number: 17, Article number : 5692, Pages count : DOI: 10.3390/molecules27175692

Authors

Nikol'skiy Vladislav V ¹ , Minyaev Mikhail E ¹ , Bastrakov Maxim A ¹ , Starosotnikov Alexey M ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry RAS, Leninsky Prosp. 47, 11991 Moscow, Russia

A number of new 2-methyl- and 2-arylvinyl-3-nitropyridines were synthesized and their reactions with thiols were studied. It was found that 3-NO2 tends to be selectively substituted under the action of sulfur nucleophiles in the presence of another nucleofuge in position 5. Correlations between the substitution pattern and regioselectivity as well as photophysical properties were established. Some synthesized compounds possessed a large Stokes shift.

Nikol'skiy V.V. , Minyaev M.E. , Bastrakov M.A. , Starosotnikov A.M.
Nucleophilic Functionalization of 2-R-3-Nitropyridines as a Versatile Approach to Novel Fluorescent Molecules
Molecules. 2022. V.27. N17. 5692 . DOI: 10.3390/molecules27175692 WOS Scopus OpenAlex

Web of science:	WOS:000851717200001
Scopus:	2-s2.0-85137579284
OpenAlex:	W4295084378

DB	Citing
OpenAlex	3
Scopus	3
Web of science	3