Green electrocatalytic Assembling of Salicylaldehydes, Kojic Acid, and Malonic Acid Derivatives into 2‐amino‐4H‐chromenes as Potent Anti‐inflammatory Agents

Green electrocatalytic Assembling of Salicylaldehydes, Kojic Acid, and Malonic Acid Derivatives into 2‐amino‐4H‐chromenes as Potent Anti‐inflammatory Agents Full article

Journal

ChemistrySelect
ISSN: 2365-6549

Output data

Year: 2022, Volume: 7, Number: 39, Article number : e202202872, Pages count : DOI: 10.1002/slct.202202872

Authors

Ryzhkova Yuliya E. ¹ , Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Kalashnikova Varvara M. ^2,1 , Korolev Victor A. ¹ , Ryzhkov Fedor V. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian academy of sciences, Leninsky pr. 47 Moscow 119991 Russian Federation
2	D. I. Mendeleev University of Chemical Technology of Russia Miusskaya sq. 9 Moscow 125047 Russian Federation

Green electrocatalytic multicomponent assembly of salicylaldehydes, kojic acid and malonic acid derivatives in n-propanol in the presence of potassium iodide as an electrolyte in an undivided cell results in the formation of 4-(3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl) substituted 2-amino-4H-chromenes in 86–98 % yields. This new electrocatalytic multicomponent process is a facile and efficient environmentally benign way to the functionalized 2-amino-4H-chromenes, containing in the fourth position kojic acid fragment, which are perspective compounds for different biomedical applications, among them in the treatment of human inflammatory diseases. Python-automated docking procedure was carried out and the results support anti-inflammatory potential of the synthesized compounds.

Ryzhkova Y.E. , Elinson M.N. , Vereshchagin A.N. , Kalashnikova V.M. , Korolev V.A. , Ryzhkov F.V. , Egorov M.P.
Green electrocatalytic Assembling of Salicylaldehydes, Kojic Acid, and Malonic Acid Derivatives into 2‐amino‐4H‐chromenes as Potent Anti‐inflammatory Agents
ChemistrySelect. 2022. V.7. N39. e202202872 . DOI: 10.1002/slct.202202872 WOS Scopus OpenAlex

Web of science:	WOS:000869777100001
Scopus:	2-s2.0-85140256258
OpenAlex:	W4306790179

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