Radical addition of tetrahydrofuran to imines assisted by tert-butyl hydroperoxide

Radical addition of tetrahydrofuran to imines assisted by tert-butyl hydroperoxide Научная публикация

Журнал

Tetrahedron Letters
ISSN: 0040-4039 , E-ISSN: 1873-3581

Вых. Данные

Год: 2020, Том: 61, Номер: 30, Номер статьи : 152150, Страниц : DOI: 10.1016/j.tetlet.2020.152150

Авторы

Vil Vera A. ¹ , Grishin Sergei S. ^1,2 , Baberkina Elena P. ² , Kostyagina Vera A. ² , Kovalenko Alexey E. ² , Terent'ev Alexander O. ^2,1

Организации

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences 47 Leninsky prosp. 119991 Moscow Russian Federation
2	D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, 125047, Moscow, Russian Federation

The TBHP-promoted selective radical addition of tetrahydrofuran to imines resulting in β-amino ethers has been developed. The presented radical method of β-amino ether synthesis is based on initiation by available TBHP and does not require metal catalysis or light irradiation. Variety of β-amino ethers are formed in good to excellent yields, despite the possible side oxidation pathways: ether α-oxidation, the transformation of starting imines into amides, target β-amino ethers dehydrogenation.

Vil V.A. , Grishin S.S. , Baberkina E.P. , Kostyagina V.A. , Kovalenko A.E. , Terent'ev A.O.
Radical addition of tetrahydrofuran to imines assisted by tert-butyl hydroperoxide
Tetrahedron Letters. 2020. V.61. N30. 152150 . DOI: 10.1016/j.tetlet.2020.152150 WOS Scopus OpenAlex

≡ Web of science:	WOS:000546924700010
≡ Scopus:	2-s2.0-85087209461
≡ OpenAlex:	W3036168419