Radical addition of tetrahydrofuran to imines assisted by tert-butyl hydroperoxide Full article
Journal |
Tetrahedron Letters
ISSN: 0040-4039 , E-ISSN: 1873-3581 |
||||
---|---|---|---|---|---|
Output data | Year: 2020, Volume: 61, Number: 30, Article number : 152150, Pages count : DOI: 10.1016/j.tetlet.2020.152150 | ||||
Authors |
|
||||
Affiliations |
|
Abstract:
The TBHP-promoted selective radical addition of tetrahydrofuran to imines resulting in β-amino ethers has been developed. The presented radical method of β-amino ether synthesis is based on initiation by available TBHP and does not require metal catalysis or light irradiation. Variety of β-amino ethers are formed in good to excellent yields, despite the possible side oxidation pathways: ether α-oxidation, the transformation of starting imines into amides, target β-amino ethers dehydrogenation.
Cite:
Vil V.A.
, Grishin S.S.
, Baberkina E.P.
, Kostyagina V.A.
, Kovalenko A.E.
, Terent'ev A.O.
Radical addition of tetrahydrofuran to imines assisted by tert-butyl hydroperoxide
Tetrahedron Letters. 2020. V.61. N30. 152150 . DOI: 10.1016/j.tetlet.2020.152150 WOS Scopus OpenAlex
Radical addition of tetrahydrofuran to imines assisted by tert-butyl hydroperoxide
Tetrahedron Letters. 2020. V.61. N30. 152150 . DOI: 10.1016/j.tetlet.2020.152150 WOS Scopus OpenAlex
Identifiers:
Web of science: | WOS:000546924700010 |
Scopus: | 2-s2.0-85087209461 |
OpenAlex: | W3036168419 |