Multicomponent protocol for the synthesis of substituted methyl 3-(3-hydroxy-4-oxo-4H-chromen-2-yl)propanoates from 3-hydroxy-4H-chromen-4-one

Multicomponent protocol for the synthesis of substituted methyl 3-(3-hydroxy-4-oxo-4H-chromen-2-yl)propanoates from 3-hydroxy-4H-chromen-4-one Full article

Journal

Synthetic Communications
ISSN: 1532-2432 , E-ISSN: 0039-7911

Output data

Year: 2022, Volume: 52, Number: 16, Pages: 1664-1671 Pages count : 8 DOI: 10.1080/00397911.2022.2107431

Authors

Komogortsev Andrey N. ¹ , Melekhina Valeriya G. ¹ , Lichitsky Boris V. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Moscow, Russian Federation

An efficient one-stage method for the preparation of substituted methyl 3-(3-hydroxy-4-oxo-4H-chromen-2-yl)propanoates was developed. The suggested approach based on multicomponent reaction of 3-hydroxy-4H-chromen-4-one with carbonyl compounds and Meldrum’s acid. The advantages of this synthesis are readily accessible starting materials, mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structures of the obtained compounds were established by 1H, 13C-NMR spectroscopy and high-resolution mass spectrometry.

Komogortsev A.N. , Melekhina V.G. , Lichitsky B.V.
Multicomponent protocol for the synthesis of substituted methyl 3-(3-hydroxy-4-oxo-4H-chromen-2-yl)propanoates from 3-hydroxy-4H-chromen-4-one
Synthetic Communications. 2022. V.52. N16. P.1664-1671. DOI: 10.1080/00397911.2022.2107431 WOS Scopus OpenAlex

Web of science:	WOS:000836117300001
Scopus:	2-s2.0-85135529765
OpenAlex:	W4289745520

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