Synthesis of 2,5-disubstituted pyrazolyl-1,3,4-oxadiazoles by the Huisgen reaction

Synthesis of 2,5-disubstituted pyrazolyl-1,3,4-oxadiazoles by the Huisgen reaction Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2022, Volume: 71, Number: 8, Pages: 1737-1744 Pages count : 8 DOI: 10.1007/s11172-022-3584-1

Authors

Shkineva T.K. ¹ , Serushkina O.V. ¹ , Vatsadze I.A. ¹ , Khoranyan T.E. ¹ , Dalinger I.L. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

We developed an approach to the synthesis of 2,5-disubstituted pyrazole-containing 1,3,4-oxadiazoles by acylation of 5-(nitropyrazolyl)tetrazoles with alkyl, aryl, and hetaryl acyl chlorides with subsequent recyclization of the intermediate N-acyltetrazoles into 1,3,4-oxadiazoles and studied nitration of the obtained 2-aryl-5-(nitropyrazolyl)-1,3,4-oxadiazoles.

Shkineva T.K. , Serushkina O.V. , Vatsadze I.A. , Khoranyan T.E. , Dalinger I.L.
Synthesis of 2,5-disubstituted pyrazolyl-1,3,4-oxadiazoles by the Huisgen reaction
Russian Chemical Bulletin. 2022. V.71. N8. P.1737-1744. DOI: 10.1007/s11172-022-3584-1 WOS Scopus OpenAlex

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