5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)

5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one) Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2022, Volume: 2022, Number: 3, Article number : M1411, Pages count : DOI: 10.3390/m1411

Authors

Ogurtsov Vladimir A. ¹ , Rakitin Oleg A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

Conjugates of 3H-1,2-dithiol-3-ones with various biologically active compounds are intensively investigated. Although many derivatives of this class have been described in the literature, the compounds containing two dithiole cycles have been explored much less. In this communication, it was shown that the reaction of 4,5-dichloro-3H-1,2-dithiol-3-one with piperazine can selectively lead to the mono-product, 4-chloro-5-piperazin-1-yl-3H-1,2-dithiol-3-one and bis-product, 5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). The structure of the synthesized compounds was established by elemental analysis, high resolution mass-spectrometry, 1H, 13C NMR and IR spectroscopy, and mass-spectrometry.

Ogurtsov V.A. , Rakitin O.A.
5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)
Molbank. 2022. V.2022. N3. M1411 . DOI: 10.3390/m1411 WOS Scopus OpenAlex

Web of science:	WOS:000856867100001
Scopus:	2-s2.0-85138660948
OpenAlex:	W4286610833

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