Synthesis and antitumor activity of bis-camptothecin ester of succinic acid | Sciact

Synthesis and antitumor activity of bis-camptothecin ester of succinic acid Научная публикация

Журнал

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Вых. Данные

Год: 2025, Том: 35, Номер: 3, Страницы: 289-291 Страниц : 3 DOI: 10.71267/mencom.7641

Авторы

Chobanov Nuri Mamedeevich ¹ , Dzhemileva Lilya Useinovna ¹ , Vakhnin Konstantin O ² , Dzhemilev Usein Memetovich ¹ , D'yakonov Vladimir Anatol'evich ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

New succinic diester containing two residues of antitumor alkaloid camptothecin has been synthesized. Its cytotoxicity and effect on cell cycle and induction of apoptosis were explored using modern methods of flow cytometry, as well as in vitro studies of the inhibitory activity against human topoisomerase I.

Chobanov N.M. , Dzhemileva L.U. , Vakhnin K.O. , Dzhemilev U.M. , D'yakonov V.A.
Synthesis and antitumor activity of bis-camptothecin ester of succinic acid
Mendeleev Communications. 2025. V.35. N3. P.289-291. DOI: 10.71267/mencom.7641 WOS Scopus OpenAlex

Web of science:	WOS:001501365000015
Scopus:	2-s2.0-105006804792
OpenAlex:	W4409003430

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OpenAlex	Нет цитирований
Scopus	Нет цитирований