Synthesis and antitumor activity of bis-camptothecin ester of succinic acid

Synthesis and antitumor activity of bis-camptothecin ester of succinic acid Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2025, Volume: 35, Number: 3, Pages: 289-291 Pages count : 3 DOI: 10.71267/mencom.7641

Authors

Chobanov Nuri Mamedeevich ¹ , Dzhemileva Lilya Useinovna ¹ , Vakhnin Konstantin O ² , Dzhemilev Usein Memetovich ¹ , D'yakonov Vladimir Anatol'evich ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

New succinic diester containing two residues of antitumor alkaloid camptothecin has been synthesized. Its cytotoxicity and effect on cell cycle and induction of apoptosis were explored using modern methods of flow cytometry, as well as in vitro studies of the inhibitory activity against human topoisomerase I.

Chobanov N.M. , Dzhemileva L.U. , Vakhnin K.O. , Dzhemilev U.M. , D'yakonov V.A.
Synthesis and antitumor activity of bis-camptothecin ester of succinic acid
Mendeleev Communications. 2025. V.35. N3. P.289-291. DOI: 10.71267/mencom.7641 WOS Scopus OpenAlex

Web of science:	WOS:001501365000015
Scopus:	2-s2.0-105006804792
OpenAlex:	W4409003430

DB	Citing
OpenAlex	Нет цитирований
Scopus	Нет цитирований