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Cycloruthenated thiophene-imines: novel anticancer agents Научная публикация

Журнал Journal of Organometallic Chemistry
ISSN: 1872-8561 , E-ISSN: 0022-328X
Вых. Данные Год: 2025, Том: 1038, Номер статьи : 123726, Страниц : DOI: 10.1016/j.jorganchem.2025.123726
Авторы Medved’ko Aleksei V. 1 , Vasil’ev Arsenii A. 1 , Kiskin Mikhail A. 2 , Syroeshkin Mikhail A. 1 , Balycheva Viсtoriya A. 1 , Melnichuk Nikolai A. 3 , Nazarov Alexey A. 3,4 , Vatsadze Sergey Z. 1
Организации
1 N.D. Zelinsky Institute of Organic Chemistry RAS, Moscow, Russia
2 N.S. Kurnakov Institute of Inorganic Chemistry RAS, Moscow, Russia
3 M.V. Lomonosov Moscow State University, Chemistry Department, Moscow, Russia
4 National Research University Higher School of Economics (HSE University), Moscow, Russia

Реферат: The search for new anticancer drugs is still a very important task for modern chemistry. Some of the most intensively studied objects are metal complexes, in particular complexes of platinum, ruthenium, iridium and osmium. To address this issue, novel organometallic ruthenium complexes with thiophene-based imines containing a Ru-C bond were synthesized and tested against cancer cell lines. The scaffold is designed to allow the generation of a broad library of cyclometallated compounds from commercially available substrates. Compounds were characterized using spectroscopic, electrochemical, and X-ray diffraction techniques. They were found to have a very good cytotoxicity among ruthenium complexes against A2780, A549 and MCF-7 cancer cells and against HEK cells.
Библиографическая ссылка: Medved’ko A.V. , Vasil’ev A.A. , Kiskin M.A. , Syroeshkin M.A. , Balycheva V.A. , Melnichuk N.A. , Nazarov A.A. , Vatsadze S.Z.
Cycloruthenated thiophene-imines: novel anticancer agents
Journal of Organometallic Chemistry. 2025. V.1038. 123726 . DOI: 10.1016/j.jorganchem.2025.123726 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: WOS:001506754300001
Scopus: 2-s2.0-105007303415
OpenAlex: W4410816980
Цитирование в БД:
БД Цитирований
Scopus 1
Web of science 1
OpenAlex 1
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