Cycloruthenated thiophene-imines: novel anticancer agents

Cycloruthenated thiophene-imines: novel anticancer agents Full article

Journal

Journal of Organometallic Chemistry
ISSN: 1872-8561 , E-ISSN: 0022-328X

Output data

Year: 2025, Volume: 1038, Article number : 123726, Pages count : DOI: 10.1016/j.jorganchem.2025.123726

Authors

Medved’ko Aleksei V. ¹ , Vasil’ev Arsenii A. ¹ , Kiskin Mikhail A. ² , Syroeshkin Mikhail A. ¹ , Balycheva Viсtoriya A. ¹ , Melnichuk Nikolai A. ³ , Nazarov Alexey A. ^3,4 , Vatsadze Sergey Z. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry RAS, Moscow, Russia
2	N.S. Kurnakov Institute of Inorganic Chemistry RAS, Moscow, Russia
3	M.V. Lomonosov Moscow State University, Chemistry Department, Moscow, Russia
4	National Research University Higher School of Economics (HSE University), Moscow, Russia

The search for new anticancer drugs is still a very important task for modern chemistry. Some of the most intensively studied objects are metal complexes, in particular complexes of platinum, ruthenium, iridium and osmium. To address this issue, novel organometallic ruthenium complexes with thiophene-based imines containing a Ru-C bond were synthesized and tested against cancer cell lines. The scaffold is designed to allow the generation of a broad library of cyclometallated compounds from commercially available substrates. Compounds were characterized using spectroscopic, electrochemical, and X-ray diffraction techniques. They were found to have a very good cytotoxicity among ruthenium complexes against A2780, A549 and MCF-7 cancer cells and against HEK cells.

Medved’ko A.V. , Vasil’ev A.A. , Kiskin M.A. , Syroeshkin M.A. , Balycheva V.A. , Melnichuk N.A. , Nazarov A.A. , Vatsadze S.Z.
Cycloruthenated thiophene-imines: novel anticancer agents
Journal of Organometallic Chemistry. 2025. V.1038. 123726 . DOI: 10.1016/j.jorganchem.2025.123726 WOS Scopus OpenAlex

Web of science:	WOS:001506754300001
Scopus:	2-s2.0-105007303415
OpenAlex:	W4410816980

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