In‐Demand and Now Available: N ‐Difluoromethylpyrazoles | Sciact

In‐Demand and Now Available: N ‐Difluoromethylpyrazoles Научная публикация

Журнал

Journal of Heterocyclic Chemistry
ISSN: 0022-152X , E-ISSN: 1943-5193

Вых. Данные

Год: 2026, DOI: 10.1002/jhet.70167

Авторы

Ugrak Bogdan ¹ , Dutova Tatyana ¹ , Rusak Vyacheslav ¹ , Tretyakov Evgeny ¹

Организации

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences Moscow Russian Federation

We report a method for the difluoromethylation of 3(5)-methylpyrazole, enabling the synthesis of two isomers: 1-(difluoromethyl)-3-methyl-1H-pyrazole and 1-(difluoromethyl)-5-methyl-1H-pyrazole. These compounds were subsequently used to prepare a range of 4-substituted N-difluoromethylated pyrazole derivatives—a transformation accomplished for the first time. The resulting derivatives serve as versatile precursors for the preparation of diverse N-difluoromethyl–substituted pyrazoles. Such compounds hold significant promise for applications across multiple research fields, ranging from materials science to medicinal chemistry.

Ugrak B. , Dutova T. , Rusak V. , Tretyakov E.
In‐Demand and Now Available: N ‐Difluoromethylpyrazoles
Journal of Heterocyclic Chemistry. 2026. DOI: 10.1002/jhet.70167 WOS Scopus OpenAlex

Поступила в редакцию:	8 окт. 2025 г.
Опубликована online:	26 янв. 2026 г.

Web of science:	WOS:001668950600001
Scopus:	2-s2.0-105028456621
OpenAlex:	W7125853964

БД	Цитирований
OpenAlex	Нет цитирований
Scopus	Нет цитирований