Abstract: We report a method for the difluoromethylation of 3(5)-methylpyrazole, enabling the synthesis of two isomers: 1-(difluoromethyl)-3-methyl-1H-pyrazole and 1-(difluoromethyl)-5-methyl-1H-pyrazole. These compounds were subsequently used to prepare a range of 4-substituted N-difluoromethylated pyrazole derivatives—a transformation accomplished for the first time. The resulting derivatives serve as versatile precursors for the preparation of diverse N-difluoromethyl–substituted pyrazoles. Such compounds hold significant promise for applications across multiple research fields, ranging from materials science to medicinal chemistry.

Cite: Ugrak B. , Dutova T. , Rusak V. , Tretyakov E.
In‐Demand and Now Available: N ‐Difluoromethylpyrazoles
Journal of Heterocyclic Chemistry. 2026. DOI: 10.1002/jhet.70167 WOS Scopus OpenAlex

Dates:

Submitted:	Oct 8, 2025
Published online:	Jan 26, 2026

Identifiers:

Web of science:	WOS:001668950600001
Scopus:	2-s2.0-105028456621
OpenAlex:	W7125853964

Citing:

DB	Citing
OpenAlex	Нет цитирований
Scopus	Нет цитирований

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