Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties

Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties Научная публикация

Журнал

Russian Journal of Applied Chemistry
ISSN: 1608-3296 , E-ISSN: 1070-4272

Вых. Данные

Год: 2025, Том: 98, Номер: 12, Страницы: 607-612 Страниц : 6 DOI: 10.1134/s107042722512002x

Авторы

Raskil’dina G.Z. ¹ , Borisova Yu.G. ¹ , Vereshchagin A.N. ² , Detusheva E.V. ^3,2 , Sultanova R.M. ¹ , Zlotskii S.S. ¹

Организации

1	Ufa State Petroleum Technological University, Ufa, Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
3	State Research Center for Applied Microbiology, Obolensk, Moscow oblast, Russia

Quaternary ammonium salts (QAS) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane moieties were synthesized (40–90% yields) based on pyridine, hexamethylenetetramine, and tertiary amines. The structure of the obtained salts was confirmed by 1H and 13C NMR spectroscopy data. The antibacterial activity of the QAS against bacterial strains (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinetobacter baumannii) was evaluated. The study showed that among the series of salts there are “leader” compounds exhibiting high antibacterial activity.

Raskil’dina G.Z. , Borisova Y.G. , Vereshchagin A.N. , Detusheva E.V. , Sultanova R.M. , Zlotskii S.S.
Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties
Russian Journal of Applied Chemistry. 2025. V.98. N12. P.607-612. DOI: 10.1134/s107042722512002x WOS Scopus OpenAlex

Поступила в редакцию:	23 мар. 2023 г.
Опубликована online:	12 февр. 2026 г.

Web of science:	WOS:001690137500004
Scopus:	2-s2.0-105029962182
OpenAlex:	W7128743912

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