Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties

Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties Full article

Journal

Russian Journal of Applied Chemistry
ISSN: 1608-3296 , E-ISSN: 1070-4272

Output data

Year: 2025, Volume: 98, Number: 12, Pages: 607-612 Pages count : 6 DOI: 10.1134/s107042722512002x

Authors

Raskil’dina G.Z. ¹ , Borisova Yu.G. ¹ , Vereshchagin A.N. ² , Detusheva E.V. ^3,2 , Sultanova R.M. ¹ , Zlotskii S.S. ¹

Affiliations

1	Ufa State Petroleum Technological University, Ufa, Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
3	State Research Center for Applied Microbiology, Obolensk, Moscow oblast, Russia

Quaternary ammonium salts (QAS) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane moieties were synthesized (40–90% yields) based on pyridine, hexamethylenetetramine, and tertiary amines. The structure of the obtained salts was confirmed by 1H and 13C NMR spectroscopy data. The antibacterial activity of the QAS against bacterial strains (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinetobacter baumannii) was evaluated. The study showed that among the series of salts there are “leader” compounds exhibiting high antibacterial activity.

Raskil’dina G.Z. , Borisova Y.G. , Vereshchagin A.N. , Detusheva E.V. , Sultanova R.M. , Zlotskii S.S.
Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties
Russian Journal of Applied Chemistry. 2025. V.98. N12. P.607-612. DOI: 10.1134/s107042722512002x WOS Scopus OpenAlex

Submitted:	Mar 23, 2023
Published online:	Feb 12, 2026

Web of science:	WOS:001690137500004
Scopus:	2-s2.0-105029962182
OpenAlex:	W7128743912

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