Annulation of aliphatic nitro compounds with β-styryl sulfonium salts toward the synthesis of isoxazoline N -oxides

Annulation of aliphatic nitro compounds with β-styryl sulfonium salts toward the synthesis of isoxazoline N -oxides Full article

Journal

Organic & Biomolecular Chemistry
ISSN: 1477-0520 , E-ISSN: 1477-0539

Output data

Year: 2026, Volume: 24, Pages: 2725–2731 Pages count : DOI: 10.1039/d6ob00176a

Authors

Ushakov Pavel Yu. ¹ , Sukhorukov Alexey Yu. ¹ , Tabolin Andrey A. ¹ , Chichulin Stepan N. ^1,2

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, 119991, Leninsky prospect, 47, Moscow, Russian Federation
2	Department of Chemistry, M. V. Lomonosov Moscow State University, 119991Leninskie gory, 1, str. 3, Moscow, Russian Federation

Vinyl sulfonium salts have proved to be convenient building blocks in modern organic synthesis due to the wide variety of their reactivities. In this study, we expand the spectrum of possible transformations using the annulation reaction with aliphatic nitro compounds as bis-nucleophilic species. The resulting isoxazoline N-oxides, which exhibit a previously difficult-to-obtain substitution pattern, turned out to be convenient precursors of valuable hydroxy ketones and polysubstituted isoxazolines.

Ushakov P.Y. , Sukhorukov A.Y. , Tabolin A.A. , Chichulin S.N.
Annulation of aliphatic nitro compounds with β-styryl sulfonium salts toward the synthesis of isoxazoline N -oxides
Organic & Biomolecular Chemistry. 2026. V.24. P.2725–2731. DOI: 10.1039/d6ob00176a WOS Scopus OpenAlex

Submitted:	Jan 30, 2026
Accepted:	Mar 5, 2026
Published online:	Mar 10, 2026

≡ Web of science:	WOS:001716867500001
≡ Scopus:	2-s2.0-105033032463
≡ OpenAlex:	W7134930877