Overcoming the Reactivity Challenge in Radical Fluoroalkylation of N ‐Phenylhydrazones: A Divergent Approach for Substrates Derived from Aliphatic and Aromatic Aldehydes

Overcoming the Reactivity Challenge in Radical Fluoroalkylation of N ‐Phenylhydrazones: A Divergent Approach for Substrates Derived from Aliphatic and Aromatic Aldehydes Научная публикация

Журнал

European Journal of Organic Chemistry
ISSN: 1434-193X , E-ISSN: 1099-0690

Вых. Данные

Год: 2026, Номер статьи : e70475, Страниц : DOI: 10.1002/ejoc.70475

Авторы

Svetlakov German V. ^1,2 , Rubanov Zakhar M. ¹ , Levin Vitalij V. ¹ , Dilman Alexander D. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry Moscow Russian Federation
2	Department of Chemistry Lomonosov Moscow State University Moscow Russian Federation

A photocatalytic method for the C–H perfluoroalkylation of N-phenylhydrazones is described. The reaction effectively utilizes both fluoroalkyl iodides and bromides as radical precursors, which enables the introduction of a wide variety of fluoroalkyl fragments. Different reaction conditions were required for hydrazones derived from aliphatic and aromatic aldehydes. The obtained α-perfluoroalkyl-substituted hydrazones serve as precursors for the synthesis of diverse heterocycles bearing a fluoroalkyl group.

Svetlakov G.V. , Rubanov Z.M. , Levin V.V. , Dilman A.D.
Overcoming the Reactivity Challenge in Radical Fluoroalkylation of N ‐Phenylhydrazones: A Divergent Approach for Substrates Derived from Aliphatic and Aromatic Aldehydes
European Journal of Organic Chemistry. 2026. e70475 . DOI: 10.1002/ejoc.70475 WOS Scopus OpenAlex

Поступила в редакцию:	14 янв. 2026 г.
Опубликована online:	24 мая 2026 г.

≡ Web of science:	WOS:001772760000001
≡ Scopus:	2-s2.0-105039699144
≡ OpenAlex:	W7162298155