Overcoming the Reactivity Challenge in Radical Fluoroalkylation of N ‐Phenylhydrazones: A Divergent Approach for Substrates Derived from Aliphatic and Aromatic Aldehydes

Overcoming the Reactivity Challenge in Radical Fluoroalkylation of N ‐Phenylhydrazones: A Divergent Approach for Substrates Derived from Aliphatic and Aromatic Aldehydes Full article

Journal

European Journal of Organic Chemistry
ISSN: 1434-193X , E-ISSN: 1099-0690

Output data

Year: 2026, Article number : e70475, Pages count : DOI: 10.1002/ejoc.70475

Authors

Svetlakov German V. ^1,2 , Rubanov Zakhar M. ¹ , Levin Vitalij V. ¹ , Dilman Alexander D. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Moscow Russian Federation
2	Department of Chemistry Lomonosov Moscow State University Moscow Russian Federation

A photocatalytic method for the C–H perfluoroalkylation of N-phenylhydrazones is described. The reaction effectively utilizes both fluoroalkyl iodides and bromides as radical precursors, which enables the introduction of a wide variety of fluoroalkyl fragments. Different reaction conditions were required for hydrazones derived from aliphatic and aromatic aldehydes. The obtained α-perfluoroalkyl-substituted hydrazones serve as precursors for the synthesis of diverse heterocycles bearing a fluoroalkyl group.

Svetlakov G.V. , Rubanov Z.M. , Levin V.V. , Dilman A.D.
Overcoming the Reactivity Challenge in Radical Fluoroalkylation of N ‐Phenylhydrazones: A Divergent Approach for Substrates Derived from Aliphatic and Aromatic Aldehydes
European Journal of Organic Chemistry. 2026. e70475 . DOI: 10.1002/ejoc.70475 WOS Scopus OpenAlex

Submitted:	Jan 14, 2026
Published online:	May 24, 2026

≡ Web of science:	WOS:001772760000001
≡ Scopus:	2-s2.0-105039699144
≡ OpenAlex:	W7162298155