Light-induced radical addition to oximes: a general route to branched primary amines Full article
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Chemical Science
ISSN: 2041-6520 , E-ISSN: 2041-6539 |
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| Output data | Year: 2026, DOI: 10.1039/d6sc05310f | ||
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Abstract:
A platform for the synthesis of branched primary amines via radical addition to unprotected oximes is described. Readily available alkyl iodides, alkanes, and carboxylic acids were used as radical precursors through XAT, HAT, and LMCT activation modes. The key feature is the use of a Brønsted acid to activate the radical addition step and to suppress side reactions. This approach is suitable for one-pot carbonyl alkylative amination, a transformation that was previously unavailable for the synthesis of primary amines.
Cite:
Rubanov Z.M.
, Levin V.V.
, Dilman A.D.
Light-induced radical addition to oximes: a general route to branched primary amines
Chemical Science. 2026. DOI: 10.1039/d6sc05310f WOS Scopus OpenAlex
Light-induced radical addition to oximes: a general route to branched primary amines
Chemical Science. 2026. DOI: 10.1039/d6sc05310f WOS Scopus OpenAlex
Dates:
| Submitted: | Jun 24, 2026 |
| Accepted: | Aug 5, 2026 |
| Published online: | Aug 6, 2026 |
Identifiers:
| ≡ Web of science: | WOS:001848048100001 |
| ≡ Scopus: | 2-s2.0-105047971876 |
| ≡ OpenAlex: | W7197007544 |