Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles

Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2026, Volume: 37, DOI: 10.71267/mencom.8110

Authors

Ugrak B.I. ¹ , Dutova T.Ya. ¹ , Tretyakov E.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Three N-alkyl-5-fluoropyrazoles were prepared from the corresponding N-alkylpyrazoles (60–64% yields) by lithiation (BuLi) at the 5-position followed by treatment with perchloryl fluoride (FClO3) in the same vessel. The obtained compounds can be regarded as versatile building blocks for the development of medicinal and agrochemical agents.

Ugrak B.I. , Dutova T.Y. , Tretyakov E.V.
Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles
Mendeleev Communications. 2026. V.37. DOI: 10.71267/mencom.8110 OpenAlex

Submitted:

Jun 8, 2026

≡ OpenAlex:

W7216501643