Conformational Lability of Bispidine as a Route to New Polycyclic Compounds

Conformational Lability of Bispidine as a Route to New Polycyclic Compounds Full article

Journal

Journal of Organic Chemistry
ISSN: 1520-6904 , E-ISSN: 0022-3263

Output data

Year: 2026, DOI: 10.1021/acs.joc.6c01744

Authors

Medved'ko Aleksei V. ¹ , Vatsadze Sergey Z. ¹

Affiliations

1	Zelinsky Institute of Organic Chemistry RAS, 119991 N.D. Moscow, Russia

In this study, novel tricyclic compounds based on bispidine were prepared via a Michael addition−Henry domino reaction. This reaction sequence proceeds under mild conditions with high diastereoselectivity. Postsynthetic transformation pathways for the resulting nitro alcohols were demonstrated, leading to tricyclic amino alcohols of various structures.

Medved'ko A.V. , Vatsadze S.Z.
Conformational Lability of Bispidine as a Route to New Polycyclic Compounds
Journal of Organic Chemistry. 2026. DOI: 10.1021/acs.joc.6c01744

Submitted:	Jul 20, 2026
Accepted:	Oct 13, 2026
Published print:	Oct 20, 2026

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