Synthesis of functionalized vinylpyridine-based phosphinic acids and their derivatives

Synthesis of functionalized vinylpyridine-based phosphinic acids and their derivatives Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 2023, Том: 72, Номер: 7, Страницы: 1576-1583 Страниц : 8 DOI: 10.1007/s11172-023-3936-5

Авторы

Prishchenko A.A. ¹ , Livantsov M.V. ¹ , Novikova O.P. ¹ , Livantsova L.I. ¹ , Baranin S.V. ² , Bubnov Yu.N. ^3,2

Организации

1	Lomonosov Moscow State University, Moscow, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
3	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russian Federation

Functionalized phosphinic acids bearing aminomethyl and 2-carboxyethyl groups were synthesized using vinylpyridines as the starting material. The radical addition of bis(trimethylsiloxy)phosphine to vinylpyridines proceeded regioselectively to give new (2-pyridinylethyl)phosphonites. The later were aminomethylated and 2-carboxyethylated to obtain the target phosphinic acids. The synthesized compounds are of interest as the promising biologically active substances and efficient ligands.

Prishchenko A.A. , Livantsov M.V. , Novikova O.P. , Livantsova L.I. , Baranin S.V. , Bubnov Y.N.
Synthesis of functionalized vinylpyridine-based phosphinic acids and their derivatives
Russian Chemical Bulletin. 2023. V.72. N7. P.1576-1583. DOI: 10.1007/s11172-023-3936-5 WOS Scopus OpenAlex

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