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Synthesis of chalcones with methylenedioxypolymethoxy fragments based on plant metabolites and study of their antiproliferative properties Научная публикация

Журнал Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285
Вых. Данные Год: 2023, Том: 72, Номер: 7, Страницы: 1632-1647 Страниц : 16 DOI: 10.1007/s11172-023-3943-6
Авторы Varakutin A.E. 1 , Muravsky E.A. 1 , Tsyganov D.V. 1 , Shinkarev I.Yu. 1 , Samigullina A.I. 1 , Kuptsova T.S. 1 , Chuprov-Netochin R.N. 2 , Smirnova A.V. 2 , Khomutov A.A. 2 , Leonov S.V. 2 , Semenova M.N. 3 , Semenov V.V. 1
Организации
1 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2 Moscow Institute of Physics and Technology, 9 Institutskii per., 141701, Dolgoprudny, Moscow Region, Russian Federation
3 N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, 26 ul. Vavilova, 119334, Moscow, Russian Federation

Реферат: Natural allylpolyalkoxybenzenes were used to synthesize polyalkoxychalcones featuring various conformations, including β-methyl-substituted S-trans-conformers and tetralone derivatives with restricted S-cis conformation. Antiproliferative antitubulin activity and cyto-toxicity of these compounds were studied using a sea urchin embryo model and human cancer cell lines. S-trans-Restricted chalcone 3y was found to exhibit high activity in the inhibition of cancer cell growth by microtubule destabilization with IC50 = 0.02–0.04 µmol L−1.
Библиографическая ссылка: Varakutin A.E. , Muravsky E.A. , Tsyganov D.V. , Shinkarev I.Y. , Samigullina A.I. , Kuptsova T.S. , Chuprov-Netochin R.N. , Smirnova A.V. , Khomutov A.A. , Leonov S.V. , Semenova M.N. , Semenov V.V.
Synthesis of chalcones with methylenedioxypolymethoxy fragments based on plant metabolites and study of their antiproliferative properties
Russian Chemical Bulletin. 2023. V.72. N7. P.1632-1647. DOI: 10.1007/s11172-023-3943-6 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: WOS:001041836400018
Scopus: 2-s2.0-85167396212
OpenAlex: W4385503842
Цитирование в БД:
БД Цитирований
OpenAlex 9
Scopus 8
Web of science 8
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