Synthesis of chalcones with methylenedioxypolymethoxy fragments based on plant metabolites and study of their antiproliferative properties

Synthesis of chalcones with methylenedioxypolymethoxy fragments based on plant metabolites and study of their antiproliferative properties Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2023, Volume: 72, Number: 7, Pages: 1632-1647 Pages count : 16 DOI: 10.1007/s11172-023-3943-6

Authors

Varakutin A.E. ¹ , Muravsky E.A. ¹ , Tsyganov D.V. ¹ , Shinkarev I.Yu. ¹ , Samigullina A.I. ¹ , Kuptsova T.S. ¹ , Chuprov-Netochin R.N. ² , Smirnova A.V. ² , Khomutov A.A. ² , Leonov S.V. ² , Semenova M.N. ³ , Semenov V.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	Moscow Institute of Physics and Technology, 9 Institutskii per., 141701, Dolgoprudny, Moscow Region, Russian Federation
3	N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, 26 ul. Vavilova, 119334, Moscow, Russian Federation

Natural allylpolyalkoxybenzenes were used to synthesize polyalkoxychalcones featuring various conformations, including β-methyl-substituted S-trans-conformers and tetralone derivatives with restricted S-cis conformation. Antiproliferative antitubulin activity and cyto-toxicity of these compounds were studied using a sea urchin embryo model and human cancer cell lines. S-trans-Restricted chalcone 3y was found to exhibit high activity in the inhibition of cancer cell growth by microtubule destabilization with IC50 = 0.02–0.04 µmol L−1.

Varakutin A.E. , Muravsky E.A. , Tsyganov D.V. , Shinkarev I.Y. , Samigullina A.I. , Kuptsova T.S. , Chuprov-Netochin R.N. , Smirnova A.V. , Khomutov A.A. , Leonov S.V. , Semenova M.N. , Semenov V.V.
Synthesis of chalcones with methylenedioxypolymethoxy fragments based on plant metabolites and study of their antiproliferative properties
Russian Chemical Bulletin. 2023. V.72. N7. P.1632-1647. DOI: 10.1007/s11172-023-3943-6 WOS Scopus OpenAlex

Web of science:	WOS:001041836400018
Scopus:	2-s2.0-85167396212
OpenAlex:	W4385503842

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OpenAlex	9
Scopus	8
Web of science	8