Prospective bacterial and fungal sources of hyaluronic acid: A review

Prospective bacterial and fungal sources of hyaluronic acid: A review Review

Journal

Computational and Structural Biotechnology Journal
ISSN: 2001-0370

Output data

Year: 2022, Volume: 20, Pages: 6214-6236 Pages count : 23 DOI: 10.1016/j.csbj.2022.11.013

Authors

Shikina E.V. ^1,2 , Kovalevsky R.A. ¹ , Shirkovskaya A.I. ¹ , Toukach Ph.V. ^1,3

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russia
2	M.V. Lomonosov Moscow State University, Department of Chemistry, Leninskie gory 1–3, 119234, 119991Moscow, Russia
3	National Research University Higher School of Economics, Myasnitskaya 20, 101000 Moscow, Russia

The unique biological and rheological properties make hyaluronic acid a sought-after material for medicine and cosmetology. Due to very high purity requirements for hyaluronic acid in medical applications, the profitability of streptococcal fermentation is reduced. Production of hyaluronic acid by recombinant systems is considered a promising alternative. Variations in combinations of expressed genes and fermentation conditions alter the yield and molecular weight of produced hyaluronic acid. This review is devoted to the current state of hyaluronic acid production by recombinant bacterial and fungal organisms.

Shikina E.V. , Kovalevsky R.A. , Shirkovskaya A.I. , Toukach P.V.
Prospective bacterial and fungal sources of hyaluronic acid: A review
Computational and Structural Biotechnology Journal. 2022. V.20. P.6214-6236. DOI: 10.1016/j.csbj.2022.11.013 WOS Scopus OpenAlex

≡ Web of science:	WOS:000953909300013
≡ Scopus:	2-s2.0-85141926519
≡ OpenAlex:	W4308929748