The multicomponent synthesis of urea substituted 2-arylfurans

The multicomponent synthesis of urea substituted 2-arylfurans Full article

Journal

Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416

Output data

Year: 2022, Volume: 111, Article number : 132716, Pages count : DOI: 10.1016/j.tet.2022.132716

Authors

Komogortsev Andrey N. ¹ , Melekhina Valeriya G. ¹ , Lichitsky Boris V. ¹ , Migulin Vasily A. ¹ , Karibov Turan T. ¹ , Minyaev Mikhail E. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr., 47, Moscow, 119991, Russian Federation

For the first time, we elaborated a one-step approach for the synthesis of 2-arylfurans containing urea moiety. The proposed method is based on multicomponent condensation of various carbo- and heterocyclic enols, arylglyoxals and cyanamide. The considered approach is general and allows one to use the various enol derivatives as starting compounds. The advantages of the studied method are the use of readily available starting compounds, atom economy, easy work-up procedure without chromatographic purification. The structure of one of synthesized products was determined by X-Ray diffraction.

Komogortsev A.N. , Melekhina V.G. , Lichitsky B.V. , Migulin V.A. , Karibov T.T. , Minyaev M.E.
The multicomponent synthesis of urea substituted 2-arylfurans
Tetrahedron. 2022. V.111. 132716 . DOI: 10.1016/j.tet.2022.132716 WOS Scopus OpenAlex

Web of science:	WOS:000788821200002
Scopus:	2-s2.0-85125910071
OpenAlex:	W4220816991

DB	Citing
OpenAlex	11
Scopus	10
Web of science	10